El-DienRatcliffeKlapsteEtAl2016

Reference

El-Dien, O. G., Ratcliffe, B., Klapste, J., Porth, I., Chen, C. and El-Kassaby, Y. A. (2016) Implementation of the realized genomic relationship matrix to open-pollinated white spruce family testing for disentangling additive from nonadditive genetic effects. G3: Genes|Genomes|Genetics, 6(3):743-753. (Scopus )

Abstract

The open-pollinated (OP) family testing combines the simplest known progeny evaluation and quantitative genetics analyses as candidates' offspring are assumed to represent independent half-sib families. The accuracy of genetic parameter estimates is often questioned as the assumption of "half-sibling" in OP families may often be violated. We compared the pedigree- vs. marker-based genetic models by analysing 22-yr height and 30-yr wood density for 214 white spruce [Picea glauca (Moench) Voss] OP families represented by 1694 individuals growing on one site in Quebec, Canada. Assuming half-sibling, the pedigree-based model was limited to estimating the additive genetic variances which, in turn, were grossly overestimated as they were confounded by very minor dominance and major additive-by-additive epistatic genetic variances. In contrast, the implemented genomic pairwise realized relationship models allowed the disentanglement of additive from all nonadditive factors through genetic variance decomposition. The marker-based models produced more realistic narrow-sense heritability estimates and, for the first time, allowed estimating the dominance and epistatic genetic variances from OP testing. In addition, the genomic models showed better prediction accuracies compared to pedigree models and were able to predict individual breeding values for new individuals from untested families, which was not possible using the pedigree-based model. Clearly, the use of marker-based relationship approach is effective in estimating the quantitative genetic parameters of complex traits even under simple and shallow pedigree structure. © 2016 El-Dien et al.

EndNote Format

You can import this reference in EndNote.

BibTeX-CSV Format

You can import this reference in BibTeX-CSV format.

BibTeX Format

You can copy the BibTeX entry of this reference below, orimport it directly in a software like JabRef .

@ARTICLE { El-DienRatcliffeKlapsteEtAl2016,
    AUTHOR = { El-Dien, O. G. and Ratcliffe, B. and Klapste, J. and Porth, I. and Chen, C. and El-Kassaby, Y. A. },
    TITLE = { Implementation of the realized genomic relationship matrix to open-pollinated white spruce family testing for disentangling additive from nonadditive genetic effects },
    JOURNAL = { G3: Genes|Genomes|Genetics },
    YEAR = { 2016 },
    VOLUME = { 6 },
    NUMBER = { 3 },
    PAGES = { 743--753 },
    ABSTRACT = { The open-pollinated (OP) family testing combines the simplest known progeny evaluation and quantitative genetics analyses as candidates' offspring are assumed to represent independent half-sib families. The accuracy of genetic parameter estimates is often questioned as the assumption of "half-sibling" in OP families may often be violated. We compared the pedigree- vs. marker-based genetic models by analysing 22-yr height and 30-yr wood density for 214 white spruce [Picea glauca (Moench) Voss] OP families represented by 1694 individuals growing on one site in Quebec, Canada. Assuming half-sibling, the pedigree-based model was limited to estimating the additive genetic variances which, in turn, were grossly overestimated as they were confounded by very minor dominance and major additive-by-additive epistatic genetic variances. In contrast, the implemented genomic pairwise realized relationship models allowed the disentanglement of additive from all nonadditive factors through genetic variance decomposition. The marker-based models produced more realistic narrow-sense heritability estimates and, for the first time, allowed estimating the dominance and epistatic genetic variances from OP testing. In addition, the genomic models showed better prediction accuracies compared to pedigree models and were able to predict individual breeding values for new individuals from untested families, which was not possible using the pedigree-based model. Clearly, the use of marker-based relationship approach is effective in estimating the quantitative genetic parameters of complex traits even under simple and shallow pedigree structure. © 2016 El-Dien et al. },
    COMMENT = { Export Date: 17 November 2016 },
    DATABASE = { Scopus },
    KEYWORDS = { Genetic variance decomposition, Genomic selection, GenPred, Mendelian sampling term, Open-pollinated families, Pedigree- and marker-based relationships, Shared data resource, breeding, Canada, controlled study, decomposition, family, family study, genetic marker, genetic model, genetic variability, height, heredity, heritability, human, major clinical study, model, pedigree, prediction, sibling, white spruce },
    OWNER = { Luc },
    TIMESTAMP = { 2016.11.17 },
    URL = { https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959570811&partnerID=40&md5=129f5aa977372be05b89ccf256a2e035 },
}

********************************************************** ***************** Facebook Twitter *********************** **********************************************************

Abonnez-vous à
l'Infolettre du CEF!

********************************************************** ***************** Pub - Mycorhizes_2019 ****************** **********************************************************

********************************************************** ***************** Pub - Symphonies_Boreales ****************** **********************************************************

********************************************************** ***************** Boîte à trucs *************** **********************************************************

CEF-Référence
La référence vedette !

Jérémie Alluard (2016) Les statistiques au moments de la rédaction 

  • Ce document a pour but de guider les étudiants à intégrer de manière appropriée une analyse statistique dans leur rapport de recherche.

Voir les autres...