XimenezGarciaFinlayNievesRamirezEtAl2018

Référence

Ximénez-García, C., Finlay, B.B., Nieves-Ramírez, M.E., Partida-Rodríguez, O., Laforest-Lapointe, I., Reynolds, L.A., Brown, E.M., Valdez-Salazar, A., Morán-Silva, P., Rojas-Velázquez, L., Morien, E., Parfrey, L.W., Jin, M., Walter, J., Torres, J., Arrieta, M.C. (2018) Asymptomatic intestinal colonization with protist Blastocystis is strongly associated with distinct microbiome ecological patterns. mSystems, 3(3). (Scopus )

Résumé

Blastocystis is the most prevalent protist of the human intestine, colonizing approximately 20% of the North American population and up to 100% in some nonindustrialized settings. Blastocystis is associated with gastrointestinal and systemic disease but can also be an asymptomatic colonizer in large populations. While recent findings in humans have shown bacterial microbiota changes associated with this protist, it is unknown whether these occur due to the presence of Blastocystis or as a result of inflammation. To explore this, we evaluated the fecal bacterial and eukaryotic microbiota in 156 asymptomatic adult subjects from a rural population in Xoxocotla, Mexico. Colonization with Blastocystis was strongly associated with an increase in bacterial alpha diversity and broad changes in beta diversity and with more discrete changes to the microbial eukaryome. More than 230 operational taxonomic units (OTUs), including those of dominant species Prevotella copri and Ruminococcus bromii, were differentially abundant in Blastocystis-colonized individuals. Large functional changes accompanied these observations, with differential abundances of 202 (out of 266) predicted metabolic pathways (PICRUSt), as well as lower fecal concentrations of acetate, butyrate, and propionate in colonized individuals. Fecal calprotectin was markedly decreased in association with Blastocystis colonization, suggesting that this ecological shift induces subclinical immune consequences to the asymptomatic host. This work is the first to show a direct association between the presence of Blastocystis and shifts in the gut bacterial and eukaryotic microbiome in the absence of gastrointestinal disease or inflammation. These results prompt further investigation of the role Blastocystis and other eukaryotes play within the human microbiome. © 2018 Nieves-Ramírez et al.

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@ARTICLE { XimenezGarciaFinlayNievesRamirezEtAl2018,
    AUTHOR = { Ximénez-García, C. and Finlay, B.B. and Nieves-Ramírez, M.E. and Partida-Rodríguez, O. and Laforest-Lapointe, I. and Reynolds, L.A. and Brown, E.M. and Valdez-Salazar, A. and Morán-Silva, P. and Rojas-Velázquez, L. and Morien, E. and Parfrey, L.W. and Jin, M. and Walter, J. and Torres, J. and Arrieta, M.C. },
    JOURNAL = { mSystems },
    TITLE = { Asymptomatic intestinal colonization with protist Blastocystis is strongly associated with distinct microbiome ecological patterns },
    YEAR = { 2018 },
    NOTE = { cited By 23 },
    NUMBER = { 3 },
    VOLUME = { 3 },
    ABSTRACT = { Blastocystis is the most prevalent protist of the human intestine, colonizing approximately 20% of the North American population and up to 100% in some nonindustrialized settings. Blastocystis is associated with gastrointestinal and systemic disease but can also be an asymptomatic colonizer in large populations. While recent findings in humans have shown bacterial microbiota changes associated with this protist, it is unknown whether these occur due to the presence of Blastocystis or as a result of inflammation. To explore this, we evaluated the fecal bacterial and eukaryotic microbiota in 156 asymptomatic adult subjects from a rural population in Xoxocotla, Mexico. Colonization with Blastocystis was strongly associated with an increase in bacterial alpha diversity and broad changes in beta diversity and with more discrete changes to the microbial eukaryome. More than 230 operational taxonomic units (OTUs), including those of dominant species Prevotella copri and Ruminococcus bromii, were differentially abundant in Blastocystis-colonized individuals. Large functional changes accompanied these observations, with differential abundances of 202 (out of 266) predicted metabolic pathways (PICRUSt), as well as lower fecal concentrations of acetate, butyrate, and propionate in colonized individuals. Fecal calprotectin was markedly decreased in association with Blastocystis colonization, suggesting that this ecological shift induces subclinical immune consequences to the asymptomatic host. This work is the first to show a direct association between the presence of Blastocystis and shifts in the gut bacterial and eukaryotic microbiome in the absence of gastrointestinal disease or inflammation. These results prompt further investigation of the role Blastocystis and other eukaryotes play within the human microbiome. © 2018 Nieves-Ramírez et al. },
    AFFILIATION = { Laboratorio de Inmunología del Departamento de Medicina Experimental, UNAM, Mexico City, Mexico; Michael Smith Laboratories, Department of Microbiology & Immunology, University of British Columbia, Vancouver, BC, Canada; Department of Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada; Department of Pediatrics, University of Calgary, Calgary, AB, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada; Department of Zoology, University of British Columbia, Vancouver, BC, Canada; Department of Botany, University of British Columbia, Vancouver, BC, Canada; Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada; School of Life Sciences, Northwestern Polytechnical University, Xi’an, China; Unidad de Investigación en Enfermedades Infecciosas, UMAE Pediatria, IMSS, Mexico City, Mexico; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada },
    ART_NUMBER = { e00007-18 },
    DOCUMENT_TYPE = { Article },
    DOI = { 10.1128/MSYSTEMS.00007-18 },
    SOURCE = { Scopus },
    URL = { https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090836334&doi=10.1128%2fMSYSTEMS.00007-18&partnerID=40&md5=d724a7a473de01c8f6855ad2c8d85a9b },
}

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